Lymphatic pathology in Wuchereria bancrofti microfilaraemic infections.
Identifieur interne : 012C17 ( Main/Exploration ); précédent : 012C16; suivant : 012C18Lymphatic pathology in Wuchereria bancrofti microfilaraemic infections.
Auteurs : S. Dissanayake [États-Unis] ; L. Watawana ; W F PiessensSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ]
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Animaux, Diéthylcarbamazine (usage thérapeutique), Femelle, Filaricides (usage thérapeutique), Filariose lymphatique (anatomopathologie), Filariose lymphatique (imagerie diagnostique), Filariose lymphatique (traitement médicamenteux), Humains, Lymphoscintigraphie, Mâle, Système lymphatique (anatomopathologie), Wuchereria bancrofti, Études longitudinales.
- MESH :
- anatomopathologie : Filariose lymphatique, Système lymphatique.
- imagerie diagnostique : Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine, Filaricides.
- Adolescent, Adulte, Animaux, Femelle, Humains, Lymphoscintigraphie, Mâle, Wuchereria bancrofti, Études longitudinales.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (diagnostic imaging), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (pathology), Female, Filaricides (therapeutic use), Humans, Longitudinal Studies, Lymphatic System (pathology), Lymphoscintigraphy, Male, Wuchereria bancrofti.
- MESH :
- chemical , therapeutic use : Diethylcarbamazine, Filaricides.
- diagnostic imaging : Elephantiasis, Filarial.
- drug therapy : Elephantiasis, Filarial.
- pathology : Elephantiasis, Filarial, Lymphatic System.
- Adolescent, Adult, Animals, Female, Humans, Longitudinal Studies, Lymphoscintigraphy, Male, Wuchereria bancrofti.
Abstract
To determine the extent of lymphatic disease in persons infected with Wuchereria bancrofti who were microfilaraemic, we examined the superficial lymphatics of the legs by scintigraphy. In 4 endemic control subjects and in 10 of 14 clinically asymptomatic microfilaraemic individuals, lymphoscintigraphy revealed one major channel of lymphatic drainage in each leg. However, while trunk lymphatics were bilaterally symmetrical in the control, marked differences in the calibre of lymphatic vessels were observed in the microfilaraemic persons. Non-discrete lymphatics and a diffuse symmetrical distribution of collateral vessels in both legs were observed in all of 5 amicrofilaraemic patients with grade 2 lymphoedema. A similar diffuse drainage pattern was also seen in 3 previously microfilaraemic persons who had remained amicrofilaraemic and asymptomatic following treatment with diethylcarbamazine citrate (DEC). Thus, clearance of microfilaraemia by DEC therapy did not appear to reverse the type of lymphatic pathology observed in microfilaraemic subjects. The lymphoscintigraphy patterns did not correlate with serum levels of antibodies to 3 recombinant filarial antigens. Virtually all the asymptomatic microfilaraemic individuals infected with W. bancrofti examined had subclinical lymphatic disease detected by the non-invasive imaging technique of lymphoscintigraphy.
PubMed: 8560529
Affiliations:
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Dissanayake</name><affiliation wicri:level="2"><nlm:affiliation>Harvard School of Public Health, Boston, MA 02115, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard School of Public Health, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Watawana, L" sort="Watawana, L" uniqKey="Watawana L" first="L" last="Watawana">L. Watawana</name></author><author><name sortKey="Piessens, W F" sort="Piessens, W F" uniqKey="Piessens W" first="W F" last="Piessens">W F Piessens</name></author></analytic><series><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><idno type="ISSN">0035-9203</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Diethylcarbamazine (therapeutic use)</term><term>Elephantiasis, Filarial (diagnostic imaging)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (pathology)</term><term>Female</term><term>Filaricides (therapeutic use)</term><term>Humans</term><term>Longitudinal Studies</term><term>Lymphatic System (pathology)</term><term>Lymphoscintigraphy</term><term>Male</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Animaux</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Femelle</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique (anatomopathologie)</term><term>Filariose lymphatique (imagerie diagnostique)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Humains</term><term>Lymphoscintigraphie</term><term>Mâle</term><term>Système lymphatique (anatomopathologie)</term><term>Wuchereria bancrofti</term><term>Études longitudinales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymphatic System</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Lymphoscintigraphy</term><term>Male</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Lymphoscintigraphie</term><term>Mâle</term><term>Wuchereria bancrofti</term><term>Études longitudinales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine the extent of lymphatic disease in persons infected with Wuchereria bancrofti who were microfilaraemic, we examined the superficial lymphatics of the legs by scintigraphy. In 4 endemic control subjects and in 10 of 14 clinically asymptomatic microfilaraemic individuals, lymphoscintigraphy revealed one major channel of lymphatic drainage in each leg. However, while trunk lymphatics were bilaterally symmetrical in the control, marked differences in the calibre of lymphatic vessels were observed in the microfilaraemic persons. Non-discrete lymphatics and a diffuse symmetrical distribution of collateral vessels in both legs were observed in all of 5 amicrofilaraemic patients with grade 2 lymphoedema. A similar diffuse drainage pattern was also seen in 3 previously microfilaraemic persons who had remained amicrofilaraemic and asymptomatic following treatment with diethylcarbamazine citrate (DEC). Thus, clearance of microfilaraemia by DEC therapy did not appear to reverse the type of lymphatic pathology observed in microfilaraemic subjects. The lymphoscintigraphy patterns did not correlate with serum levels of antibodies to 3 recombinant filarial antigens. Virtually all the asymptomatic microfilaraemic individuals infected with W. bancrofti examined had subclinical lymphatic disease detected by the non-invasive imaging technique of lymphoscintigraphy.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><noCountry><name sortKey="Piessens, W F" sort="Piessens, W F" uniqKey="Piessens W" first="W F" last="Piessens">W F Piessens</name><name sortKey="Watawana, L" sort="Watawana, L" uniqKey="Watawana L" first="L" last="Watawana">L. Watawana</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Dissanayake, S" sort="Dissanayake, S" uniqKey="Dissanayake S" first="S" last="Dissanayake">S. Dissanayake</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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